The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage. eukaryotic cells have developed a sophisticated molecular machinery, called the DNA damage response (DDR), to detect, signal?and repair the DNA lesions (1,3,5,6). The DDR executes a variety of responses such as cell-cycle checkpoint activation, DNA repair, apoptosis and senescence (5C8). … Continue reading The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage